The importance of this study is due to the fact that patients with COVID-19 are associated with long-term symptoms, however the variety, frequency and severity of these as well as the complications have not been fully understood. For this study, a systematic review was carried out which included studies that investigated the frequency and variety of symptoms after COVID-19 infection, through a search through PubMed and Web of Science, including studies from January 1, 2020 to March 2021. Persistent symptoms were defined as those that persisted for at least 60 days after diagnosis, onset of symptoms or hospitalization, or at least 30 days after recovery from the acute event or hospital discharge. Of the 1974 studies, 47 were used that did meet eligibility, reporting 84 clinical signs and symptoms which were included in the study. A total of 9,751 participants were included, with a mean age less than 60 years, most of whom had been hospitalized, where it was found that the participants presented at least 1 symptom persistently, giving a total of 72.5%; where the most common symptoms were dyspnea (27.5-50%), fatigue (31-57%), sleep disturbances (24.4-33%), cough and chest pain (16.9-60%), anosmia, ageusia and dysgeusia were found (12.4-10.7%), but the latter were not reported by all studies. The review found that COVID-19 symptoms persist after the acute phase of the disease, severely affecting people's quality of life. Among the limitations that were presented was that the exact duration of the persistent symptoms could not be known, and that there was heterogeneity between the studies, mainly due to the standards for the times of onset of the disease and the symptoms that were included.