This multi-sector cohort study aimed to understand risk factors associated with developing COVID-19 after full vaccination. A total of 152 patients from 17 hospitals in Israel who received two doses of the BNT162b2 vaccine, had a PCR-confirmed diagnosis of SARS-CoV-2 infection, and were hospitalized for COVID-19 were included in the study. Patient demographics consisted of a median age of 71.1 (range 22-98), 70% males, and 25% residents of a long-term care facility. Comorbidities were present in 96% of patients and 40% were immunosuppressed. Though most patients were unaware of the source of infection, 12% were exposed to an infected household member and 11% were exposed in healthcare settings to another patient. Patient mortality rate was 22%, similar to unvaccinated COVID-19 patients who are hospitalized. Aside from higher upper-respiratory viral load, the study was unable to determine a significant risk factor for mechanical ventilation or in-hospital death. Overall, authors encourage prospective longitudinal studies to identify additional predictors for post-vaccine SARAS-CoV-2 infection.