There is limited information on the characteristics of COVID-19 patients disaggregated by race/ethnicity. Therefore, this study aims to examine the characteristics and factors associated with SARS-CoV-2 infection, COVID-19 hospitalization, and hospital mortality in a large, diverse patient population in a large healthcare system. which operates in California, Oregon, and Washington. This retrospective cohort study was conducted between March 1, 2020, and December 31, 2020. Minority populations including Hispanic, Black, Asian, Native Hawaiian, and Pacific Islander (NH / PI), and American Indian and Native Alaskans (AI / AN) were more likely to be infected SARS-CoV-2 compared to whites in the adjusted and unadjusted analysis. While racial/ethnic minority patients accounted for 27.8% of patients screened for SARS-CoV-2, they made up 50.1% of SARS-CoV-2 infected patients and 54.3% of patients hospitalized for COVID-19. Hispanic patients, in particular, accounted for 34.3% of those infected with SARS-CoV-2 and 35.3% of hospitalized patients despite being younger and generally having fewer comorbidities than white patients and representing only 13.4% of the patients evaluated a pattern consistent with state-level statistics. While this study cannot identify the causes behind the observed associations, certain social, structural, or biological determinants of health have been suggested. Additional studies are needed to identify the causal factors driving disparities in COVID-19.