In order to understand the vulnerability of children to the SARS-CoV-2 disease, Haslak et al. conducted a retrospective study to assess the clinical features and outcomes of multi-system inflammatory syndrome (MIS-C) in children under 18 years old between July and March 2021. The medical records of 76 patients (52 males) were collected in three referral centers with diagnosis and treatment criteria of MIS-C established by the CDC. All patients with MIS-C admitted to the hospital were tested and patients experiencing hemodynamic instability were admitted to the pediatric intensive care unit (PICU) by PICU intensivists. The results of the analysis showed that 15.8% of the patients were admitted to the PICU due to an underlying chronic disease. As reported by the parents, a majority of patients had taken proper precautions when they suspected COVID-19-related MIS-C. Among all the patients, 17 reported negative results for anti-SARS-CoV-2 immunoglobulin (Ig) G positivity, and of those 5 tested positive in the polymerase-chain reaction (PCR) test. The least frequent systems involved were renal and neurologic (10.5%, 18.4%) while the most frequent were gastrointestinal and cardiac (85. 5%, 93.4%). All patients were monitored for changes in inflammation and were in the PICU for a median of 4 days and a median of 8 days in the hospital. A majority of patients had ethnographic abnormities (60.5%). One patients cranial CT screenings revealed active bleeding, which ended fatally, while the remaining 75 patients recovered without readmittance. The authors concluded that there is a need to raise awareness of the clinical features and outcomes of MIS-C is necessary to address the risk of COVID-19 and to further expand studies about this condition across a wide range of cultural backgrounds.