Effective control of SARS-CoV-2 transmission in Wanzhou, China

November 30, 2020

Shi Q, Hu Y, Peng B, et al.

Nature Medicine

This study assessed data from 5 generations of transmission of SARS-CoV-2 in 183 confirmed COVID-19 cases and their contacts in Wanzhou, China. Among the cases, 67.2% were symptomatic and 32.8% were asymptomatic. Upon analysis, the reproductive number was calculated as 1.64 (95% CI: 1.16-2.40) from the first to the second generation of transmission. This number decreased in subsequent generations of transmission to 0.31-0.39; this decrease coincided with the implementation of strict control measures. There was evidence for higher risk of infection with the following factors: interaction with infected case within 5 days of being infected (OR: 2.88, 95% CI: 1.22-6.78), repeated contact with the case (OR: 2.89, 95% CI: 1.39-6.02), and greater than 8 hours of contact (OR: 6.08, 95% CI: 2.88-12.83). Understanding the key risk factors and implementing rigorous control measures are essential for the mitigation and prevention of COVID-19 resurgence.

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