Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis

November 2, 2020

Francesca Di Toro, Mattheus Gjoka, Giovanni Di Lorenzo, Davide De Santo, Francesco De Seta, Gianpaolo Maso, Francesco Maria Risso, Federico Romano, Uri Wiesenfeld, Roberto Levi-D'Ancona, Luca Ronfani, Giuseppe Ricci.

Clinical Microbiology and Infection

Pregnancy has an important influence on the immune status, studies have shown that viral diseases such as influenza and being pregnant predispose to more severe manifestations, two meta-analyzes have shown that pregnant women have a higher risk of a worse prognosis. For the meta-analysis of this systematic review, articles that spoke of COVID 19, pregnancy and perinatal prognosis were taken into account, as well as articles with original information, that is, cohort, retrospective and case-control studies. PubMed, EMBASE, MedRxiv, Scholar, Scopus, and Web of Science were used as databases. 1779 articles were identified, of which 24 were taken into account in the meta-analysis, 1100 pregnant women were included, all of them Chinese, European or North American, 512 underwent PCR and 72 had a negative result but the CDC determined them as COVID cases Due to clinical and radiological manifestations, the other 508 patients were considered COVID cases by clinical evaluation. Generally, the prognosis in pregnant women and newborns is good, and the manifestations are usually very similar to that in the adult population in general, there is no evidence of vertical transmission and the authors mention the need for prospective studies to clarify the true risks of COVID in pregnancy. The authors have no conflict of interest.

Di Toro F et al., Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis, Clinical Microbiology and Infection, 2020; Vol 27:36-46

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