Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study
February 8, 2021
Francesca Crovetto, Fàtima Crispi, Elisa Llurba, Rosalia Pascal, Marta Larroya, Cristina Trilla, Marta Camacho, Carmen Medina, Carlota Dobaño, Maria Dolores Gomez-Roig, Francesc Figueras, Eduard Gratacos, KidsCorona Pregnancy COVID-19 group
Clinical Infectious Diseases
This document presents a prospective multicenter population-based cohort study that included early and late pregnant women from the catchment areas of three hospitals in Barcelona, Spain from March 15 to May 31, 2020. It was carried out universal screening for SARS-CoV-2 infection and evaluated its impact on pregnancy outcomes. Among women with infection, 68.5% did not. The rate of symptomatic cases and hospital admissions was higher in late pregnancy compared to early pregnancy. The risk of a pregnancy complication was similar in women with and without SARS-CoV-2 exposed early or late in pregnancy. However, symptomatic women with COVID-19 had a modest but significant increased risk of preterm delivery and intrapartum fetal distress. The ICU admission rate among symptomatic women in the third trimester of COVID-19 was 4.2% (3/71), for those with symptoms during labor it was 10.7% (3/28 ) and for those with pneumonia, 42.9%. The results support that vertical transmission of SARS-CoV-2 is very rare. Vaginal delivery was achieved in the majority of women with clinically active COVID-19 during labor, supporting the safety of such an approach. This study supports that the impact of SARS-CoV-2 infection on pregnancy outcomes is small or negligible.
Crovetto F., Crispi F., Llurba E., Pascal R. Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study. Clinical Infectious Diseases 2021, https://doi.org/10.1093/cid/ciab104