Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study

February 8, 2021

Francesca Crovetto, Fàtima Crispi, Elisa Llurba, Rosalia Pascal, Marta Larroya, Cristina Trilla, Marta Camacho, Carmen Medina, Carlota Dobaño, Maria Dolores Gomez-Roig, Francesc Figueras, Eduard Gratacos, KidsCorona Pregnancy COVID-19 group

Clinical Infectious Diseases

This document presents a prospective multicenter population-based cohort study that included early and late pregnant women from the catchment areas of three hospitals in Barcelona, ​​Spain from March 15 to May 31, 2020. It was carried out universal screening for SARS-CoV-2 infection and evaluated its impact on pregnancy outcomes. Among women with infection, 68.5% did not. The rate of symptomatic cases and hospital admissions was higher in late pregnancy compared to early pregnancy. The risk of a pregnancy complication was similar in women with and without SARS-CoV-2 exposed early or late in pregnancy. However, symptomatic women with COVID-19 had a modest but significant increased risk of preterm delivery and intrapartum fetal distress. The ICU admission rate among symptomatic women in the third trimester of COVID-19 was 4.2% (3/71), for those with symptoms during labor it was 10.7% (3/28 ) and for those with pneumonia, 42.9%. The results support that vertical transmission of SARS-CoV-2 is very rare. Vaginal delivery was achieved in the majority of women with clinically active COVID-19 during labor, supporting the safety of such an approach. This study supports that the impact of SARS-CoV-2 infection on pregnancy outcomes is small or negligible.

Crovetto F., Crispi F., Llurba E., Pascal R. Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study. Clinical Infectious Diseases 2021, https://doi.org/10.1093/cid/ciab104

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