Neuropsychiatric aspects of COVID-19 pandemic: A selective review

May 30, 2020

Damodharan Dinakaran, Narayana Manjunatha, Channaveerachari Naveen Kumar, Bada Math Suresh

Asian Pacific Journal of clinical nutrition

It is believed that there are several mechanisms by which the virus affects the central nervous system, highlighting the direct neuro invasion of the virus, through the hematogenous route or through the neural route of smell, this thanks to the activation of the enzyme receptor angiotensin converting that is present in the capillary and neuronal endothelium. Immune alterations secondary to these processes are believed to be the cause of neuropsychiatric sequelae. In this article, databases were used to find articles that related COVID 19 with the neuropsychiatric manifestations of the disease, in the first cut 188 articles were obtained, of which only 12 were eligible to continue in the final review. Headache, taste and smell alterations are one of the most prevalent alterations in patients with COVID 19, there are also reports of meningitis, encephalitis, encephalopathy, cerebrovascular disease, seizures, Sx. Guillian-Barre and other neuropathies. The neuropsychiatric sequelae are still not very clear, however, there is a growing concern in this area among experts. COVID has been linked to an increase in the prevalence of delirium, cognitive problems, insomnia, suicides, and psychosis. There is evidence that relates the development of psychotic disorders in up to 4% of patients infected with COVID, this related to the disease as such, to the treatment, and to the psychosocial stress of the pandemic itself.

Dinakaran, D., Manjunatha, N., Kumar, CN., Suresh, BM. Neuropsychiatric aspects of COVID-19 pandemic: A selective review. Asian Jornual of psychiatry, 2020; Vol. 53