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Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study
June 26, 2021
Aris T. Papageorghiou MD, Philippe Deruelle PhDd, Robert B. Gunier PhD, Stephen Rauch MPH, Perla K.García-May MD, Mohak Mhatre MD, Mustapha Ado Usman MBBS, Sherief Abd-Elsalam PhD, Saturday Etuk MD, Lavone E. Simmons MD, Raffaele Napolitano PhD, Sonia Deantoni MD, Becky Liu MBBS, Federico Prefumo PhD, Valeria Savasi PhD, Marynéa Silvado Vale MD, Eric Baafi MD, Ghulam Zainab FCPS, Ricardo Nieto MD, Nerea Maiz PhD, Muhammad BaffahAminu FWACS, Jorge Arturo Cardona-Perez MD, Rachel Craik BS, Adele Winsey PhD, Gabriela Tavchioska MS, Babagana Bako MD, Daniel Oros PhD, Albertina Rego PhD, Anne Caroline Benski MD,Fatimah Hassan-Hanga FMCP, Mónica Savorani MD, Francesca Giuliani PhD, Loïc Sentilhes PhD, Milagros Risso MD, Ken Takahashi PhD, Carmen Vecchiarelli, MD, SatoruIkenoue MD, Ramachandran Thiruvengadam MD, Constanza P. Soto MD, Enrico Ferrazzi MD, Irene Cetin MD, Vincent Bizor Nachinab MD, Ernawati Ernawati PhD, Eduardo A.Duro MD, Alexey Kholin MD, Michelle L. Firlit MD, Sarah Rae Easter MD, Joanna Sichitiu MD, Abimbola Bowale MD, Roberto Casale PhD, Rosa Maria Cerbo MD, Paolo Ivo Cavoretto PhD, Brenda Eskenazi PhD, Jim G.Thornton MD, Zulfiqar A. Bhutta PhD, Stephen H. Kennedy MD, José Villar MD.
ScienceDirect
INTERCOVID is a multinational, prospective study on COVID-19’s impact on pregnant mothers and neonates. Over 2000 pregnant women were enrolled from March 2020 to February 2021, of whom a third were diagnosed with COVID-19. Among those diagnosed, 8% had preeclampsia (RR 1.77, 95% CI 1.25-2.52). After adjusting for factors associated with preeclampsia, the association remained statistically significant for nulliparous women (RR 1.89, 95% CI 1.17-3.05). Risk ratio of preterm birth for women with COVID-19 but not preeclampsia was 1.57 (95% CI 1.27-1.95), and 80% of these were medically indicated, as opposed to 61% in women with neither condition. There is implication that COVID-19 and preeclampsia in pregnant mothers are associated. Severity of COVID-19 infection was not found to affect the association between COVID-19 and preeclampsia. Findings indicate the vulnerability of women with preeclampsia to the risks associated with COVID-19.
Papageorghiou AT, Deruelle P, Gunier RB, et al. Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study. Am J Obstet Gynecol 2021; published online June 26. DOI:10.1016/j.ajog.2021.05.014.
