The pandemic consequence of the SARS-CoV-2 virus has been related as a risk factor for mental health throughout the world. Clinically, infection by this pathogen begins with a picture of acute respiratory failure, which in its worst cases leads to multi-organ failure, so the kidney can be one of the targets of this pathogen, which can trigger some associated kidney abnormalities, including proteinuria, hematuria and acute kidney injury, this COVID-19 pandemic has generated deterioration of mental health in health sector professionals, its situation being unknown in nurses caring for patients with chronic kidney disease.The objective of this research is to be able to identify psychological well-being and its differences according to demographic and professional variables in nurses who perform hemodialysis in times of COVID-19, through a quantitative, descriptive cross-sectional study, carried out in 52 nurses who perform hemodialysis. renal replacement therapy in intensive care and renal therapy units in times of COVID-19. Sociodemographic, academic, and labor variables were obtained, and the PGWBI scale was used to establish levels of psychological well-being. The Mann-Whitney and Kruskall-Wallis tests were used, performing Dunn's post test to compare differences between the variables studied.High levels of psychological well-being were identified in nurses who provide care to patients undergoing renal replacement therapy in times of the COVID-19 pandemic, where factors such as marital status, post-graduation training and having job stability with better salary income, positively influence the categories that contributed to the results of psychological well-being of the nurses evaluated.