A systematic review analyzed a series of patients presenting stroke as a complication and prognosis in patients with a history of stroke. Similar to other coronaviruses it can access the nervous system through the blood or retrograde axonal transport, probably associated with anosmia. Before entering the cells it binds to ACE2 receptors. It analyzes 214 patients with COVID-19 between January and February 2020, 36.4% had a neurological manifestation including stroke. Stroke was reported in 2.8% of the total cohort, 5.7% had a severe respiratory infection, and 0.8% mild infections. Within the patients with severe neurological damage had higher levels of D-dimer and immunosuppression. The second issue addressed is whether the history of stroke increases the risk of developing COVID-19 and the severity of the symptoms. In Chinese population, 40% had a personal history of cardiovascular disease or stroke. In all case series studies history of stroke was associated with a worse progression of COVID-19. The mechanisms that may cause stroke are invasion of vessels when the virus binds the receptor ACE2, coagulation disorders, cerebral embolism secondary to myocardial damage, destabilization of an existing atheroma plaque.