Thrombosis risk associated with COVID-19 infection. A scoping review

August 1, 2020

Al-Ani F, Chehade S, Lazo-Langner A.

Thromb Res.

Recent findings suggested a prominent increase in D-dimer levels as a predictor of adverse outcomes suggesting the presence of underlying coagulopathy. We conducted a literature search using Medical subject headings (MeSH) in PubMed, it included randomized control trials, observational cohort studies, case series. The studies suggested the higher D-dimer level was associated with the severity of the disease in COVID-19, however, new data showed conflicting evidence. Overall, the evidence reported a significant increase in D-dimer, and it seems to continue to rise as the disease progresses. There was no difference in prothrombin time, platelet count between patients in the ICU and non-ICU, but there was a higher prothrombin time, platelet count <100 in non-survivors than survivors. Several studies suggest substantial coagulation activation.

Al-Ani F, Chehade S, Lazo-Langner A. Thrombosis risk associated with COVID-19 infection. A scoping review. Thromb Res. 2020 Aug;192:152-160. doi: 10.1016/j.thromres.2020.05.039.

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