Indigenous populations are especially vulnerable to COVID-19 because of the higher rates of poverty, morbidity and mortality they face compared to their non-indigenous neighbours. The authors propose an approach with two different phases to mitigate the effects of COVID-19 on the indigenous population and ensure a collaborative and effective plan that includes all stakeholders in the decision process. The first phase includes a mutual collaboration with tribal leaderships to conduct research, coordinate with regional government/public health authorities, provide PPE and medical care, and ensure collective decision making to isolate by regulating interactions of villagers. Phase two involves contact tracing, patient management, case reporting, and isolation responses for individuals who were diagnosed with COVID-19.