Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus
September 11, 2020
Elrashdy F, Redwan EM, Uversky VN.
There is convincing evidence that CoVs can use multiple pathways to enter the host cell. SARS-CoV entry into cells could occur by direct fusion of envelopes with the plasma membrane on the cell surface. It can also take advantage of the target cell's endocytic machinery. SARS-CoV enters cells by endosomal pathways, where protein S is activated for fusion by a trypsin-like protease in an acidic endosomal environment. There is also the potential for non-endosomal entry of a virus into the cell Guest. Here, proteases, such as trypsin and thermolysin, promote the access of SARS-CoV cells directly from the site where this virus is adsorbed on the cell surface.
Elrashdy F, Redwan EM, Uversky VN. Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus Epidemics? Biomolecules. 2020 Sep 11;10(9):1312. doi: 10.3390/biom10091312. PMID: 32933047; PMCID: PMC7565143.