Fuchs et al sought to assess the safety of using hotels for COVID-19 isolation and quarantine for people experiencing homelessness with confirmed or suspected COVID-19 and how this system relates to inpatient hospital capacity. This retrospective cohort study assessed 1,009 persons who were transferred to isolation/quarantine hotels from hospitals, outpatient settings, and public health surveillance programs in San Francisco, California in the spring of 2020. Of the guests who were positive for COVID-19, only 4% needed to be readmitted to a hospital. The authors found the isolation/quarantine hotel system to be associated with preserving hospital inpatient capacity; they also found that this system was implemented rapidly and safely to deliver medical and behavioral care. The authors found that premature discontinuation of isolation/quarantine occurred in 19% of patients and was more likely to occur among the unsheltered homeless and more likely to occur among persons in isolation due to an exposure vs. an active infection.