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Highly sensitive quantification of plasma SARS-CoV-2 RNA shelds light on its potential clinical value
August 17, 2020
David Veyer, Solen Kernéis, Geoffroy Poulet, et al.
Clinical Infectious Diseases
Plasma SARS-CoV-2 viral load (SARS-CoV-2 RNAaemia) was quantified by droplet-based digital PCR technology and compared in 58 COVID-19 patients and 12 healthy controls. 17 patients were categorized as mild-to-moderate, 16 were categorized as severe, and 26 were categorized as critical. SARS-CoV-2 RNAaemia was detected in 43 (74.1%) of patients. Both the prevalence and levels of positive SARS-CoV-2 RNAaemia was correlated with disease severity (ranging from 53% in mild-to-moderate to 88% in critical patients). Droplet-based digital PCR technology used to detect SARS-CoV-2 RNAaemia represents a promising prognostic tool for COVID-19.
David Veyer, Solen Kernéis, Geoffroy Poulet, Maxime Wack, Nicolas Robillard, Valérie Taly, Anne-Sophie L’Honneur, Flore Rozenberg, Pierre Laurent-Puig, Laurent Bélec, Jérôme Hadjadj, Benjamin Terrier, Hélène Péré, Highly sensitive quantification of plasma SARS-CoV-2 RNA shelds light on its potential clinical value, Clinical Infectious Diseases, , ciaa1196, https://doi.org/10.1093/cid/ciaa1196
