This community-based participatory study examined the impact of the COVID-19 pandemic on people experiencing homelessness and the services they use in Tippecanoe County, Indiana. 18 semi-structured interviews were conducted with key informants from 15 community-based organizations (CBOs) such as shelters and homeless support services. Multiple individual (e.g., poor health and hygiene), interpersonal (e.g., fear of social isolation), organizational (e.g., disruption of services), community (e.g., community support, interagency collaborations) and policy (e.g., lack of appropriate guidance and funding) factors were identified across the socio-ecological model for people experiencing homelessness during the pandemic. Multi-level emergency interventions were being provided by the CBOs to address these challenges. Emergency pandemic measures also brought innovative and sustainable solutions to existing long-standing challenges facing people experiencing homelessness. The study concluded that CBOs are uniquely placed to inform pandemic and emergency responses specific to the needs of people experiencing homelessness, and these responses need to be individualized to local contexts and community.