Lactoferrin is a protective factor in human milk and a key component of the innate response of mammals to infections. Lactoferrin can prevent viral infections by interacting with the cellular heparin sulfate glycosaminoglycan (HSPG) receptors, which allow the first docking site on the cell surface in the first phase of viral infections and in coronaviruses in particular. After docking, viruses accumulate on the cell surface and recognize more virus-specific receptors. These include the receptor for angiotensin converting enzyme 2 (ACE2), a metallopeptidase that can latch onto the terminals of the virus and facilitate entry into the cell. SARS - CoV - 2 is transmitted mainly through respiratory droplets, it can invade enterocytes, cause symptoms and act as a reservoir. Lactoferrin promotes the growth of a favorable gut microbiota and the proliferation of enterocytes with direct anti-inflammatory and immunomodulatory actions. These effects and mechanisms have not been proven in SARS - CoV - 2, but clinicians might consider this approach as they have affected other coronaviruses.