Researchers studied the effect of an 8-week COVID-19 lockdown in Khurda district of Odisha, India on management of multimorbidity. Using a cross sectional design and statistical analysis, researchers interviewed 600 people (300 urban, 300 rural). The mean age of participants was 55 and average duration of chronic diseases was 9 years. Data showed that hypertension was the most common disease (44%), followed by diabetes (36%, more prevalent in urban areas), musculoskeletal morbidities (15%, more prevalent in rural areas) and acid peptic diseases (9%, more prevalent in rural). Overall, around 40% of participants had multimorbidity (122 urban, 115 rural). During the lockdown, changes in routine-checkups were most altered for those with multimorbidity, with statistically significant differences seen in changes in daily routine, worse physical activity, worse continuation of treatment, and dietary changes more prevalent for urban versus rural dwellers. Additionally, those with multimorbidity faced more challenges in managing diseases, with most pressing issues of physician consultation and diagnostic investigations. Factors that influenced this included transportation, financial, and mobility issues, and fear of getting COVID-19 during the lockdown. Additionally, females and younger individuals were more likely to face challenges than males. Finally, physical and mental health were worse for those with multimorbidity. These results show that efforts should be taken during the COVID-19 pandemic to mitigate the worse effects of multimorbidity, with telemedicine, self-care, and patient education.