This study used five different mathematical models to estimate the effect of the COVID- 19 pandemic on excess mortality related to HIV as well as new HIV infections across sub-Saharan Africa (SSA). The primary analysis estimated the effect of 50% of the population having interrupted HIV care for a 6-month period, including the lack of access to anti-retroviral therapy (ART), HIV prevention services, and HIV testing. The models suggest that a 6-month interruption of ART would lead to 1.63 times the number of HIV-related deaths within a year, compared to if there was no interruption. This increase translates to an additional 296,000 HIV-related deaths across SSA over a 1- year period. The models estimate that new HIV infections may increase up to 1.19 times during this same period due to disruptions in outreach and condom programs; however, if physical distancing leads to reduced sex with non-regular partners, it is possible there might be a net reduction in new infections.