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SARS-CoV-2 and stroke characteristics: A report from the multinational COVID-19 stroke study group6
April 21, 2021
Shima Shahjouei, Georgios Tsivgoulis, Ghasem Farahmand, Eric Koza, Ashkan Mowla, Alireza Vafaei Sadr, Arash Kia, Alaleh Vaghefi Far, Stefania Mondello, Achille Cernigliaro, Annemarei Ranta, Martin Punter, Faezeh Khodadadi, Soheil Naderi, Mirna Sabra, Mahtab Ramezani, Ali Amini Harandi, Oluwaseyi Olulana, Durgesh Chaudhary, Aicha Lyoubi, Bruce C.V. Campbell, Juan F. Arenillas, Daniel Bock, Joan Montaner, Saeideh Aghayari Sheikh Neshin, Diana Aguiar de Sousa, Matthew S. Tenser, Ana Aires, Mercedes de Lera Alfonso, Orkhan Alizada, Elsa Azevedo, Nitin Goyal, Zabihollah Babaeepour, Gelareh Banihashemi, Leo H. Bonati, Carlo W. Cereda, Jason J. Chang, Miljenko Crnjakovic, Gian Marco De Marchis, Massimo Del Sette, Seyed Amir Ebrahimzadeh, Mehdi Farhoudi, Ilaria Gandoglia, Bruno Gonçalves, Christoph J. Griessenauer, Mehmet Murat Hanci, Aristeidis H. Katsanos, Christos Krogias, Ronen R. Leker, Lev Lotman, Jeffrey Mai, Shailesh Male, Konark Malhotra, Branko Malojcic, Teresa Mesquita, Asadollah Mir Ghasemi, Hany Mohamed Aref, Zeinab Mohseni Afshar, Jusun Moon, Mika Niemelä, Behnam Rezai Jahromi, Lawrence Nolan, Abhi Pandhi, Jong-Ho Park, João Pedro Marto, Francisco Purroy, Sakineh Ranji-Burachaloo, Nuno Reis Carreira, Manuel Requena, Marta Rubiera, Seyed Aidin Sajedi, João Sargento-Freitas, Vijay K. Sharma, Thorsten Steiner, Kristi Tempro, Guillaume Turc, Yasaman Ahmadzadeh, Mostafa Almasi-Dooghaee, Farhad Assarzadegan, Arefeh Babazadeh, Humain Baharvahdat, Fabricio Buchadid Cardoso, Apoorva Dev, Mohammad Ghorbani, Ava Hamidi, Zeynab Sadat Hasheminejad, Sahar Hojjat-Anasri Komachali, Fariborz Khorvash, Firas Kobeissy, Hamidreza Mirkarimi, Elahe Mohammadi-Vosough, Debdipto Misra, Ali Reza Noorian, Peyman Nowrouzi-Sohrabi, Sepideh Paybast, Leila Poorsaadat, Mehrdad Roozbeh, Behnam Sabayan, Saeideh Salehizadeh, Alia Saberi, Mercedeh Sepehrnia, Fahimeh Vahabizad, Thomas Alexandre Yasuda, Mojdeh Ghabaee, Nasrin Rahimian, Mohammad Hossein Harirchian, Afshin Borhani-Haghighi, Mahmoud Reza Azarpazhooh, Rohan Arora, Saeed Ansari, Venkatesh Avula, Jiang Li, Vida Abedi, Ramin Zand
Stroke
This study aimed to understand the risk of stroke, the severity of stroke, and the type of stroke that occurred in patients with COVID-19 across 32 countries and 136 tertiary centres. Among 432 patients, all of which were diagnosed with COVID-19, 57.6% were men, 24.1% were over 55 years old, 37.8% had symptoms of stroke, and 24.4% did not present with vascular risk. Additionally, 74.8% presented with acute ischemic stroke (AIS), 21.1% with intracranial haemorrhage (ICH), and 4.2% with cerebral venous or sinus thrombosis (CVST). Of the patients with acute ischemic stroke, 33% had large artery atherosclerosis, 27% had cardio-embolism, 44.5% had large vessel occlusion (LVO), and 10% had small artery occlusion. Overall, the study found that this cohort of AIS patients who were also diagnosed with COVID-19, were younger, more often male, and approximately one third had an asymptomatic SARS-CoV-2 infection as compared to available population-level information from before the COVID-19 pandemic. In addition, this cohort included fewer small artery occlusion and lacunar infarcts, and more LVO strokes, as compared to pre-pandemic population-level data.
Shahjouei S, Tsivgoulis G, Farahmand G, et al. SARS-CoV-2 and Stroke Characteristics. Stroke 2021; 52. DOI:10.1161/STROKEAHA.120.032927.
