The human intestine has one of the highest expressions of angiotensin-converting enzyme (ACE2) receptors in the body, the receptor SARS-CoV and SARS-CoV-2 viruses use to enter target cells. Lamers et al. used human small intestinal organoids, tiny 3D cell cultures of gut epithelial cells, to determine if SARS-CoV and SARS-CoV-2 can directly infect and replicate within the cells of the gut. Both viruses were observed to rapidly and productively infect the gut, suggesting human small intestinal organoids may be an appropriate in vitro model to study SARS-CoV-2.