Data from 239 affected meat and poultry processing facilities across 23 states was collected through May 31, 2020. 16,233 positive cases and 86 COVID-19 related deaths were identified. Demographic information was collected from workers in 21 states; 87% of cases occurred in racial/ethnic minorities and 46% were aged 40-59 years. Among cases for which symptom status was reported, 12% of workers were asymptomatic or presymptomatic. The study investigators emphasized the importance of workplace-specific interventions and prevention strategies to minimize occupational risk and health disparities among vulnerable populations. Suggested strategies for these facilities include temperature and symptom screening, mandated face coverings, increased COVID-19 education, physical barriers between workers, and the addition of hand hygiene stations.