Two domestic cats living in households in the United States with persons who were positive or suspected positive for COVID-19 were confirmed to be infected with SARSCoV-2 by RT-PCR. Symptoms exhibited by the cats included sneezing, coughing, nasal and ocular discharge, lethargy, and loss of appetite. Both cats fully recovered. While human-to-animal transmission of the SARS-CoV-2 virus can occur, animals are not suspected of playing a major role in spreading COVID-19. However, this One Health study suggests that animals that test positive for SARS-CoV-2 should be kept separate from other animals and humans, and humans with suspected or confirmed COVID-19 should similarly limit contact with animals.