During the COVID-19 pandemic, it was necessary to implement mandatory quarantine, in order to contain the spread of the virus, a situation that generated changes in the lifestyles of the population, this could alter the ability of individuals to perceive time , and thereby affect their mental health. Time has been an intriguing phenomenon, object of study since ancient times for all civilizations. The definition of time has been a difficult task to tackle and a dichotomy has been proposed to conceptualize it: There is physical or objective time, susceptible to measurement, and subjective or psychological time.The objective of this research was to synthesize the neurological bases of the phenomenon of time perception, its importance and the scientific evidence on possible alterations in quarantine conditions, through the thematic bibliography in Pubmed, Medline, Scopus, and Google Scholar databases. . The search terms in Spanish and English included: time perception, time estimation, pandemic, cognition, emotional states, mental health, describing the concept of time perception, its neurological bases and the alterations that can be generated.In conclusion, it can be affirmed that mental health was affected by the pandemic, however, the way in which this affectation developed in the medium and long term is clearly unknown.